Microfluidic actuators based on temperature-responsive hydrogels
Patrtick Tabeling
Institut Pierre-Gilles de Gennes, Research University Paris, France
Abstract
The idea of using stimuli-responsive hydrogels to actuate fluids in microfluidc devices is attractive, but limitations, in terms of spatial resolution, speed, reliability and integration, has hindered its development during the last two decades. By using a novel technological approach, we could realize devices including thousands of actuated micro-cages that sequester and releases solutes along with valves actuated individually with switch times of 300 ms. Two applications of this technology are illustrated for the domains of single cell handling and NAAT (nuclear acid amplification test) for Human Synaptojanin 1 gene, suspected to be involved in Parinson disease.
Curriculum Vitae
Dr. Patrick Tabeling is directeur de Recherches CNRS, Professor ESPCI, and director of the Institut Pierre-Gilles de Gennes. Since 2001, he is leader of the group MMN (Microfluidics MEMS and Nanostructures) composed of 20 researchers (permanents, PhDs and Postdoctoral students). He occupied various positions in different laboratories: Visiting researcher in Chicago University (1984-1985), Charge/Directeur de Recherches CNRS in the Department of Physics in ENS (1985-2001), visiting professor to UCLA, now Directeur de Recherches/Professor at ESPCI. He was professor charge de cours at the Ecole Polytechnique (1996-2008). He is the author of 200 papers (120in refereed journals), 9 patents (4500 citations, h factor 40), 75 invited talks in international conferences; he is divisionnal editor of Physical Review Letters, Associate Editor of Physics of Fluids and Biomicrofluidics, guest editor of CARS and PNAS. He published the book entitled "An introduction to microfluidics" (Oxford University Press - a French version being edited by Belin) in 2005. Since 2011, he is the director of the Institut Pierre-Gilles de Gennes, a new research institution dedicated to microfluidics and its applications.
